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Recombinant Mouse Fibrinogen gamma chain protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1837

Print datasheet

Synonyms

Fgg, Fibrinogen gamma chain

验证数据展示

  • Purity of Recombinant Mouse Fibrinogen gamma chain was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Fibrinogen gamma chain was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Fibrinogen gamma chain protein Val168-Val436 (Accession# Q8VCM7) with a rabbit IgG Fc tag at the C-terminus.
基因ID 99571
蛋白编号 Q8VCM7
预测分子量 56.7 kDa
SDS-PAGE 55-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia. FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.

参考文献:

1.Nencini, F. et al. (2024) Mol Biomed. 5(1):45.
2.Dobson, DA.et al. (2024) Thromb res. 242:109134.
3.Huang, Y. et al. (2024) Int j biol macromol. 274(Pt 1):133286.
4.Mosesson, MW. et al. (2005) J Thromb Haemost. 3(8):1894-904.
5.Personnaz, J. et al. (2024) Hemasphere. 8(7):e115.