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Recombinant Mouse Epor protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2711

Print datasheet

Synonyms

Epor, EPO-R, Erythropoietin receptor

验证数据展示

  • Purity of Recombinant Mouse Epor was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Epor was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Epor protein Ala25-Pro249 (Accession# P14753-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 13857
蛋白编号 P14753-1
预测分子量 50.7 kDa
SDS-PAGE 55-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Erythropoietin (EPO) receptor (EPOR) is a glycoprotein that belongs to the type I superfamily of single-transmembrane cytokine receptors. It consists of an extracellular domain that binds to the EPO ligand, transmembrane, and intracellular domains. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. EPOR is present in erythroid progenitor cells and has also been detected in various non-hematopoietic cells.

参考文献:

1. Ribatti D. et al. (2012). Int Rev Cell Mol Biol. 299:199-234. 
2.Tóthová Z. et al. (2021). Int J Mol Sci. 22(13):7109. 
3.Awida Z. et al. (2022). Int J Mol Sci. 23(19):12051.