• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
Use Able AI chat for product recommendations

Recombinant Mouse EGFR protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3498

Print datasheet

Synonyms

EC:2.7.10.1, EGF R, Erbb, erbb 1, Erbb1

验证数据展示

  • Purity of Recombinant Mouse EGFR was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse EGFR was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse EGFR was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse EGFR was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse EGFR protein Leu25-Ser647 (Accession# Q01279) with a rabbit IgG Fc tag at the C-terminus.
基因ID 13649
蛋白编号 Q01279
预测分子量 95.6 kDa
SDS-PAGE 100-120 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

EGFR (Epidermal Growth Factor Receptor) is a receptor for epithelial growth factor (EGF) cell proliferation and signaling and belongs to the ErbB receptor family, also known as HER1 or ErbB1.It is a glycoprotein, a tyrosine kinase-type receptor, with a cell-membrane penetration, and a molecular weight of approximately 170 kDa. EGFR EGFR is located on the surface of the cell membrane and is activated by binding to ligands, including EGF and TGFα. Upon activation, EGFR is converted from a monomer to a dimer, and activation activates its intracellular kinase pathways, including the MAPK, Akt, and JNK pathways, which induces cellular proliferation. Mutations in or overexpression of EGFR generally lead to tumorigenesis, and have been associated with the development of a variety of cancers, including lung cancer, anogenital carcinoma, and polymorphic glioblastoma, and glioblastoma multiforme, among others. (PMID: 37036745)

参考文献:

1. Voldborg BR, et al. Ann Oncol. 1997;8(12):1197-206.                                            
2. Talukdar S, et al. Adv Cancer Res. 2020;147:161-188.                                            
3. Sapmaz A, et al. Oncotarget. 2023;14:297-301.
||
New chat Able
正在加载，请稍候...