Recombinant Mouse CD226 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD226 protein Glu19-Pro254 (Accession# Q8K4F0) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 225825 |
| 蛋白编号 | Q8K4F0 |
| 预测分子量 | 53.1 kDa |
| SDS-PAGE | 55-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD226 (DNAM-1) is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 acts as an adhesion molecule guiding immune cells to bind to target cells and mediate the formation of immune synapses. It also mediates cytotoxicity and promotes the production of cytokines by transmitting intracellular signals. The protein also plays a role in megakaryocytic cell maturation. Interactions of CD226 and its ligands, CD155 and CD112, induce NK and T cell-mediated cytotoxicity and cytokine secretion.
参考文献:
1. Chan CJ, et al. (2012). Curr Opin Immunol. 24(2):246-251. 2. Huang Z, et al. (2020). Front Cell Dev Biol. 8:564. 3. Tahara-Hanaoka S, et al. (2004). Int Immunol. 16(4):533-538.
