Recombinant Mouse Cardiotrophin-1 protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Cardiotrophin-1 protein Ser2-Ala203 (Accession# Q60753) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 13019 |
| 蛋白编号 | Q60753 |
| 预测分子量 | 48.0 kDa |
| SDS-PAGE | 51-58 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Ctf1 is a multifunctional cytokine that plays a crucial role in cardioprotection, neuroprotection, and glucose metabolism. Mouse models have been used to study the function of Ctf1 in various disease states, and its human ortholog CT1 is a promising candidate for the development of therapeutic strategies for metabolic and neurological disorders. Cardiotrophin-1 (CTF1) is a member of the IL-6 family of cytokines and has been shown to protect cardiac cells against ischemia/reperfusion injury, inhibit apoptotic cell death, and enhance liver regeneration after hepatectomy. It is also expressed in the embryonic limb bud and is secreted by differentiated myotubes. CTF1 has been shown to exhibit impressive neuroprotective effects and delay the progression of motor neuron degenerative disorders such as amyotrophic lateral sclerosis (ALS), progressive motor neuropathy (PMN), and spinal muscular atrophy (SMA). It also protects cortical neuronal cells against free radical-induced oxidative stress, excitatory damage, and sodium nitroprusside (SNP)-induced neurotoxic effects.
参考文献:
1. Zhou S, Li Z, et al. (2024) J Adv Res. S2090-1232(24)00183-8. 2. Wang D, Li X, et al. (2013) Pharmacol Biochem Behav. 107:48-57. 3. Lutz SZ, Franck O, et al. (2014) PLoS One. 9(7):e100391. 4. Jiménez-González M, et al. (2013) Diabetologia. 56(4):838-46.
