Recombinant Mouse G-CSFR protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse G-CSFR protein Cys26-Asp626 (Accession# P40223) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 12986 |
| 蛋白编号 | P40223 |
| 预测分子量 | 94.0 kDa |
| SDS-PAGE | 150-180 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Csf3r, or the colony-stimulating factor 3 receptor (CSF3R), is a protein that is vital for the regulation of granulopoiesis, neutrophil function, and hematopoietic stem cell mobilization (PMID: 29572350). CSF3R is also expressed in various tissues, with biased expression in the bone marrow, appendix, and other tissue.Mutations in the CSF3R gene can lead to various hematological disorders. Acquired activating heterozygous variants in CSF3R are the main cause of chronic neutrophilic leukemia, a hyperproliferative disorder, while biallelic germ line hypomorphic variants in CSF3R are a rare cause of severe congenital neutropenia, a hypoproliferative condition. Additionally, heterozygous germ line CSF3R variants have been identified as risk alleles for developing both myeloid and lymphoid malignancies (PMID: 33108454).
参考文献:
1. Zhang H. et al. (2018). J Biol Chem. 293(19):7387-7396. 2. Trottier AM. (2020). Blood Adv. 4(20):5269-5284.
