Recombinant Mouse Dectin-1 protein (rFc Tag)(HPLC verified)
种属
Mouse
纯度
>90 %, SDS-PAGE
>90%, SEC-HPLC
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90%, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Dectin-1 protein Gly71-Leu244 (Accession# Q6QLQ4) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 56644 |
| 蛋白编号 | Q6QLQ4 |
| 预测分子量 | 45.8 kDa |
| SDS-PAGE | 48-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
C-type lectin structural domain family 7 member A (Clec7a), also known as Dectin-1, is a transmembrane protein containing an intracellular immune receptor tyrosine-based activation (ITAM)-like motif and an extracellular C-type lectin-like structural domain for recognition. Clec7a has important roles in the innate immune system, particularly in the recognition of β-glucans. Studies have revealed potential links between Clec7a and a variety of biological processes such as immune homeostasis, autoimmunity, allergy, and cancer. Clec7a regulates phagocytosis by macrophages in a variety of peripheral tissues. Clec7a is upregulated in microglial cells during neurodegeneration and is an important receptor for microglial cell activation in response to AD pathology. (PMID: 39088351)
参考文献:
1. Wan H, et al. (2024). Adv Sci (Weinh). 11(36):e2403064. 2. Wang J, et al. (2024). Front Immunol. 15:1361351. 3. Wang Y, et al. (2022). Front Immunol. 13:1008727.
