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Recombinant Mouse CHIT1 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2808

Print datasheet

Synonyms

Chitinase-1, Chitotriosidase-1, EC:3.2.1.14

验证数据展示

  • Purity of Recombinant Mouse CHIT1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CHIT1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse CHIT1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse CHIT1 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse CHIT1 protein Ala22-Ser464 (Accession# Q9D7Q1-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 71884
蛋白编号 Q9D7Q1-1
预测分子量 74.9 kDa
SDS-PAGE 68-75 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CHIT1 (Chitinase 1) is a chitinase, a member of the 18-glycosylase family (GH18), that has been implicated in the pathology of a variety of lung diseases. CHIT1 cleaves chitin polymers and plays a role in digestion and absorption, as well as the innate immune system. CHIT1-positive microglial cells are specifically present in the spinal cord of aging primates and can be paracrine through the CHIT1 activates SMAD signaling in motor neurons, which in turn drives motor neuron senescence, and the concentration of CHIT1 in cerebrospinal fluid (CSF) at diagnosis is a reliable predictor of faster disability progression in multiple sclerosis (MS) patients.

参考文献:

1. Sun S, et al. Nature. 2023;624(7992):611-620.                                                     
2. Beliën J, et al. Nat Commun. 2024;15(1):5013.                                                         
3. Dymek B, et al. J Inflamm Res. 2022;15:5621-5634.                                               
4. Sklepkiewicz P, et al. Eur J Pharmacol. 2022;919:174792.
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