Recombinant Mouse CD74 protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD74 protein Gln56-Leu279 (Accession# P04441-1) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 16149 |
| 蛋白编号 | P04441-1 |
| 预测分子量 | 52.1 kDa |
| SDS-PAGE | 52-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD74, also known as MHC class II invariant chain Ii or HLA-DR-associated invariant chain, is a non-polymorphic type II transmembrane glycoprotein. CD74 is mainly distributed in B cells, monocytes, Langerhans cells, dendritic cells and thymic epithelial cells, and is also expressed in epithelial cells. CD74 plays a key role in MHC class II antigen processing and also serves as a cell surface receptor for the macrophage cytokine MIF. CD74 plays an important role in cardiovascular diseases such as atherosclerosis, ischemic heart disease, and myocardial hypertrophy.
参考文献:
1. Burton JD, et al. (2004). Clin Cancer Res.1;10(19):6606-11. 2 .Su H, et al. (2017). Inflamm Res. 66(3):209-216. 3 . Zhang L, et al. (2024). Cell Mol Life Sci.11;81(1):296. 4.Li QL, et al. (2023). Front Cardiovasc Med. 12;9:1049143.
