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Recombinant Mouse CEACAM-1/CD66a protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1423

Print datasheet

Synonyms

Bgp, Bgp1, BGP-1, Biliary glycoprotein 1, Biliary glycoprotein D

验证数据展示

  • Purity of Recombinant Mouse CEACAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CEACAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse CEACAM-1 protein Glu35-Gly428 (Accession# P31809-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 26365
蛋白编号 P31809-1
预测分子量 69.9 kDa
SDS-PAGE 80-120 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CEACAM1, also known as BGP1 or CD66a, belongs to the CEA-related cell-adhesion molecule (CEACAM) subfamily, which is a part of the immunoglobulin superfamily. It plays a role in cell-cell adhesion, regulation of cell proliferation, insulin resistance, obesity, and vascular homeostasis. CEACAM1 is expressed by certain epithelial, endothelial, lymphoid, and myeloid cells. It is found on the surface of various tumors and is associated with tumor progression, metastasis and poor prognosis. CEACAM1 serves as a specific biomarker for Non-small cell lung cancer (NSCLC) and can be used for diagnosis and prognosis of melanoma.

参考文献:

1. Muenzner P. et al. (2007). Cell Microbiol. 10(5):1074-92.
2. Rueckschloss U. et al. (2016). Histochem Cell Biol. 146(6):657-671.
3. Dankner M. et al. ( 2017). Oncoimmunology. 6(7):e1328336.
4. Gray-Owen SD. et al. (2006). Nat Rev Immunol. 6(6):433-46.
5. Gur C, et al. (2019). Oncoimmunology. 8(6):e1581531.