Recombinant Mouse CD83 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD83 protein Met22-Arg133 (Accession# O88324) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12522 |
| 蛋白编号 | O88324 |
| 预测分子量 | 38.6 kDa |
| SDS-PAGE | 42-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD83 is a member of the immunoglobulin (Ig) superfamily, consisting of an extracellular V-type Ig-like domain, a transmembrane domain, and a cytoplasmic tail. CD83 is one of the most prominent markers for fully matured dendritic cells (DCs). It is also found on the surface of other activated hematopoietic cells, including lymphocytes, monocytes, macrophages, and neutrophils. CD83 regulates the maturation, activation, and homeostasis of numerous immune cells. CD83 can also expressed as a soluble form. Soluble CD83 can bind to DCs and inhibit their maturation.
参考文献:
1. Prechtel AT. et al. (2007). Arch Dermatol Res. 299(2):59-69. 2. Li Z. et al. (2019). Front Immunol. 10:1312. 3. Grosche L. et al. (2020). Front Immunol. 11:721. 4. Lechmann M. et al. (2002). Int Arch Allergy Immunol. 129(2):113-8.
