Recombinant Mouse CD39/ENTPD1 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD39 protein Thr38-Ile478 (Accession# P55772) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12495 |
| 蛋白编号 | P55772 |
| 预测分子量 | 75.7 kDa |
| SDS-PAGE | 85-120 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD39/ENTPD1 is a rate-limiting extracellular nucleotidase that hydrolyzes ATP/ADP into AMP, which, in coordination with CD73, generates adenosine. This process converts pro-inflammatory "danger signals" into an immunosuppressive microenvironment. CD39 is highly expressed on regulatory T cells, tumor-associated cells, and endothelial cells, playing a critical role in maintaining immune homeostasis, suppressing inflammation, and regulating thrombosis by establishing an adenosine-rich microenvironment. This molecule has emerged as an important therapeutic target in tumor immunotherapy and autoimmune diseases, with its specific inhibitors already entering clinical research stages.
参考文献:
1. Xia, Chenglai et al. Molecular cancer vol. 22,1 (2023): 44. 2. Moesta, Achim K et al. Nature reviews. Immunology vol. 20,12 (2020): 739-755. 3. Shen, Jie et al. Molecular biomedicine vol. 6,1 (2025): 97. 4. Savio, Luiz Eduardo Baggio et al. Journal of hepatology vol. 67,4 (2017): 716-726.
