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Recombinant Mouse CD32B/Fcgr2b protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg5259

Print datasheet

Synonyms

CD32, Fcgr2, Fcgr2b, FcgRII, Fcr 2

验证数据展示

  • Purity of Recombinant Mouse CD32B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD32B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse CD32B protein Thr30-Pro210 (Accession# P08101-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 14130
蛋白编号 P08101-1
预测分子量 46.6 kDa
SDS-PAGE 55-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD32B, also known as FcgammaRIIb or FCGR2B, is a protein that belongs to the family of Fc receptors. It is a type I transmembrane protein and a member of the immunoglobulin superfamily of low-affinity immunoglobulin gamma Fc receptors. This protein acts as a low-affinity receptor for the Fc region of immunoglobulin gamma complexes. It plays a crucial role in immune responses, particularly in the phagocytosis of immune complexes. CD32B is involved in several processes, including Fc-gamma receptor signaling pathway involved in phagocytosis, negative regulation of B cell receptor signaling pathway, and regulation of dendritic spine maintenance. It is expressed in various cell types, such as B cells, myeloid cells, and is also found on the surface of B cell leukemia/lymphoma cells. The protein is encoded by the FCGR2B gene and is implicated in various diseases, including autoimmune thrombocytopenic purpura, glomerulonephritis, lymphoid leukemia, malaria, and systemic lupus erythematosus.

参考文献:

1.Stopforth RJ. et al. (2016) J Clin Immunol. 36 Suppl 1:88-94.
2.Tutt AL. et al. (2015) J Immunol. 195(11):5503-16.
3.Lim SH. et al. (2011) Blood. 118(9):2530-40.