Recombinant Mouse CD200R1 protein (His tag)
种属
Mouse
纯度
>95 %, SDS-PAGE
标签
His tag
生物活性
EC50: 5-19 ng/mL
验证数据展示
产品信息
| 纯度 | >95 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Immobilized Mouse CD200R1 (His tag) at 1 μg/mL (100 μL/well) can bind Mouse CD200 (hFc tag) with a linear range of 5-19 ng/mL. |
| 来源 | HEK293-derived Mouse CD200R1 protein Thr26-Pro238 (Accession# Q9ES57) with a His tag at the C-terminus. |
| 基因ID | 57781 |
| 蛋白编号 | Q9ES57 |
| 预测分子量 | 23.9 kDa |
| SDS-PAGE | 40-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cell surface glycoprotein CD200 receptor 1 (CD200R1), also named as CD200R, CRTR2, MOX2R and OX2R, belongs to the CD200R family. It is a type I transmembrane glycoprotein containing two Ig-like domains in the extracellular region, a transmembrane and a cytoplasmic domain. CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200 is expressed on a variety of cells of hematopoietic and non-hematopoietic origin, while CD200R1 is primarily expressed by myeloid and T cell lineage. The CD200-CD200R interaction plays a role in immunosuppression and suppression of anti-tumor immune responses.
参考文献:
1. Gavin J Wright, et al. (2003). J Immunol. 171(6):3034-46. 2. Reginald Gorczynski, et al. (2004). J Immunol. 172(12):7744-9. 3. T P Rygiel, et al. (2012). Oncogene. 31(24):2979-88.
