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验证数据展示

  • WB analysis using 13436-1-AP (same clone as 13436-1-PBS)

    WB analysis using 13436-1-AP (same clone as 13436-1-PBS)

    Jurkat lysates were subjected to SDS PAGE followed by western blot with 13436-1-AP (MTUS1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13436-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 13436-1-AP (same clone as 13436-1-PBS)

    WB analysis of mouse brain using 13436-1-AP (same clone as 13436-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 13436-1-AP (MTUS1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13436-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 13436-1-AP (same clone as 13436-1-PBS)

    IHC staining of human breast cancer using 13436-1-AP (same clone as 13436-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 13436-1-AP (MTUS1 antibody) at dilution of 1:600 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13436-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 13436-1-AP (same clone as 13436-1-PBS)

    IP experiment of mouse brain using 13436-1-AP (same clone as 13436-1-PBS)

    IP result of anti-MTUS1 (IP:13436-1-AP, 4ug; Detection:13436-1-AP 1:500) with mouse brain tissue lysate 6000ug. This data was developed using the same antibody clone with 13436-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-3 using 13436-1-AP (same clone as 13436-1-PBS)

    IF Staining of PC-3 using 13436-1-AP (same clone as 13436-1-PBS)

    Immunofluorescent analysis of (-20℃ Ethanol) fixed PC-3 cells using 13436-1-AP (MTUS1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 13436-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MTUS1 Polyclonal antibody, PBS Only

MTUS1 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 13436-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

13436-1-PBS targets MTUS1 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4242

Product name: Recombinant human MTUS1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-240 aa of BC033842

Sequence: MQLQEQFDNLNAAHETSKLEIEASHSEKLELLTKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 mitochondrial tumor suppressor 1
别名
计算分子量 51 kDa, 141 kDa
观测分子量 40-48 kDa, 80 kDa, 110-120 kDa, 270-280 kDa
GenBank蛋白编号BC033842
基因名称 MTUS1
Gene ID (NCBI) 57509
RRIDAB_10638619
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9ULD2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706). The antibody can recognize all the isoforms expect isoform 5(85-90 kDa). The antibody tested HomoDimer isoforms (80kd/110-120/280kd) in Jurkat cell.

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