Recombinant Human TNFSF18 protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TNFSF18 protein Gln50-Ser177 (Accession# Q9UNG2) with a His tag at the N-terminus. |
| 基因ID | 8995 |
| 蛋白编号 | Q9UNG2 |
| 预测分子量 | 20.9 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
TNFSF18 is also named as Glucocorticoid-induced TNF-related ligand (hGITRL). GITR is a gene coding for a member of the TNF receptor superfamily. GITR activation by its ligand (GITRL) influences the activity of effector and regulatory T cells, thus participating in the development of immune response against tumours and infectious agents, as well as in autoimmune and inflammatory diseases. GITR-GITRL interactions co-stimulate both responder T-cell functions and the suppressive functions of TReg cells. GITRL is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
参考文献:
1. Nocentini, Giuseppe et al. European journal of immunology vol. 37,5 (2007): 1165-9. 2. Shevach, Ethan M, and Geoffrey L Stephens. Nature reviews. Immunology vol. 6,8 (2006): 613-8. 3. Lacal, Pedro Miguel et al. The Journal of pharmacology and experimental therapeutics vol. 347,1 (2013): 164-72.