Recombinant Human TNFRSF21/DR6 protein (rFc Tag)(HPLC verified)
种属
Human
纯度
>90 %, SDS-PAGE
>90 %, SEC-HPLC
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90 %, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TNFRSF21 protein Gln42-His349 (Accession# O75509) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 27242 |
| 蛋白编号 | O75509 |
| 预测分子量 | 59.5 kDa |
| SDS-PAGE | 68-95 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
DR6 (also known as TNFRSF21 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells. DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis. DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease.
参考文献:
1. Colombo A, et al. (2018) EMBO J. 37(7):e97390. 2. Pan G, et al. (1998) FEBS Lett. 431(3):351-6. 3. Nikolaev A, et al. (2009) Nature. 457(7232):981-9.
