Recombinant Human TIMP4 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TIMP4 protein Cys30-Pro224 (Accession# Q99727) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 7079 |
| 蛋白编号 | Q99727 |
| 预测分子量 | 48.7 kDa |
| SDS-PAGE | 48-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Endogenous inhibitors of matrix metalloproteinases (MMPs) called tissue inhibitors of matrix metalloproteinases (TIMPs) form a family of four members,TIMP1-4. Although possessing many similarities, TIMPs show several structural and biochemical differences, and their expression patterns differ. TIMP4 is characterized by being primarily restricted to cardiovascular structures. Experimental studies have suggested a role for TIMP4 in cardiovascular disorders exhibiting an inflammatory component. Overexpression of TIMP4 has been observed within the arterial wall in rats after a balloon injury. TIMP4 has been shown to suppress vascular smooth muscle cell migration and induce cell apoptosis and to inhibit capillary endothelial cell migration.
参考文献:
1. Baker AH.et al. (2002)J Cell Sci.115:3719-3727. 2. SpinaleFG.et al.(2002) Circ Res.90:520-530. 3.LiYY.et al. (1999) Cardiovasc Res.42:162-72. 4. Schulze CJ.et al. (2003) Circulation.107:2487-92. 5. Guo YH.et al. (2004)Life Sci.75:2483-93.
