Recombinant Human TFF2 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TFF2 protein Glu24-Tyr129 (Accession# Q03403) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 7032 |
| 蛋白编号 | Q03403 |
| 预测分子量 | 38.0 kDa |
| SDS-PAGE | 37-45 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The trefoil factor family (TFF), comprises of three polypeptides, TFF1, TFF2 and TFF3 (7-12 kDa), secreted to mucosal surfaces by mucus producing cells, prominently in the gastrointestinal tract. TFF2, also known as spasmolytic polypeptide, is a low-molecular weight protein, expressed in mucous neck cells of the fundus and glands at the base of the antrum in normal human stomach. TFF2 expression is observed ectopically during stone diseases, chronic inflammatory conditions and in several metaplastic and neoplastic epithelia. TFF2 could Inhibit gastrointestinal motility and gastric acid secretion. Recent studies suggest that TFF2 could also play an important role in the immune system.
参考文献:
1. Takako K, et al. (2021). Int J Gynecol Pathol. Jan;40(1):65-72. 2. Jiang Z, et al. (2023). Cell stem cell. Aug 3;30(8):1091-1109.e7. 3. Hoffmann W. (2015). Int J Oncol. Sep;47(3):806-16.
