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Recombinant Human TFF1 protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3073

Print datasheet

Synonyms

Breast cancer estrogen-inducible protein, HP1.A, pNR 2, PNR-2, Polypeptide P1.A

验证数据展示

  • Purity of Recombinant Human TFF1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TFF1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human TFF1 was greater than 90% as determined by SEC-HPLC.

    The purity of Human TFF1 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human TFF1 protein Glu25-Phe84 (Accession# P04155) with a rabbit IgG Fc tag at the C-terminus.
基因ID 7031
蛋白编号 P04155
预测分子量 32.7 kDa
SDS-PAGE 35-40 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TFF1 (Trefoil factor 1, formerly known as pS2) is a small-secreted protein that belongs to the family of trefoil peptides, and characterized by the presence of one to six cysteine-rich P domains. TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene. The function of TFF1 was first controversially considered as an oncogene in breast cancer.

参考文献:

1. Li J, Xia N, et al. (2022) Adv Sci (Weinh). 9(9):e2104338. 
2. Okamoto M, Kuratani A, et al. (2024) Front Immunol. 15:1440918. 
3. Busch MA, Haase A, et al. (2022) Cancers (Basel). 14(3):677. 
4. Shah A, Jahan R, et al. (2024) Cancer Lett. 598:217097.
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