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Recombinant Human TDP-43 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1877

Print datasheet

Synonyms

TARDBP, TDP 43, TDP43, TDP-43, ALS10

验证数据展示

  • Purity of Recombinant Human TDP-43 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TDP-43 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human TDP-43 protein Met1-Thr103 (Accession# Q13148-1) with a His tag at the C-terminus.
基因ID 23435
蛋白编号 Q13148-1
预测分子量 12.5 kDa
SDS-PAGE 14-17 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TARDBP was firstly found as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It was also reported to regulate alternate splicing of the CFTR gene. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in Amyotrophic lateral sclerosis (ALS).

参考文献:

1. Neumann M, et al. (2006) Science. 314(5796):130-3. 
2. Foulds PG, et al. (2006) Acta Neuropathol. 118(5):647-58.
3. Guo W,  et al. (2011) Nat Struct Mol Biol. 18(7):822-30. 
4. Dharmalingam K, et al. (2012) J Ethnopharmacol. 139(2):657-63.