Recombinant Human SIGLEC14 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human SIGLEC14 protein Glu17-Leu358 (Accession# Q08ET2) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 100049587 |
| 蛋白编号 | Q08ET2 |
| 预测分子量 | 64.3 kDa |
| SDS-PAGE | 65-80 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
SIGLEC14, also known as sialic acid-binding immunoglobulin-like lectin 14, is a member of the Siglec family, which is expressed on myeloid cells and plays a role in recognizing bacterial pathogens, eliciting pro-inflammatory responses. SIGLEC14 is primarily a transmembrane protein found on the surface of myeloid cells. A soluble form of SIGLEC14 is also present in human blood, which is derived from an alternatively spliced mRNA that retains intron 5, preventing the translation of the transmembrane domain. It has been implicated in various diseases, particularly in the context of immune responses and inflammation.
参考文献:
1.Huang PJ. et al. (2018). J Biol Chem. 293(51):19645-19658. 2.Angata T. (2014). Glycobiology. 24(9):785-793. 3.Tsai CM. et al. (2020). J Innate Immun. 12(4):333-343.
