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Recombinant Human SPINT2/HAI-2 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3130

Print datasheet

Synonyms

SPINT2, HAI2, HAI-2, Kop, Kunitz-type protease inhibitor 2

验证数据展示

  • Purity of Recombinant Human SPINT2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human SPINT2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human SPINT2 protein Ala28-Lys197 (Accession# O43291-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 10653
蛋白编号 O43291-1
预测分子量 45.2 kDa
SDS-PAGE 48-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

SPINT2 (serine peptidase inhibitor Kunitz type 2), also known as hepatocyte growth factor activator inhibitor type-2(10), belongs to the Kunitz family of serine protease inhibitors, which is a plasma membrane-localized serine protease inhibitor found in epithelial cells of various tissues including the respiratory tract and all major organs. SPINT2 possesses one transmembrane domain and two kunitz-type inhibitor domains that are exposed to the extracellular space and which are believed to facilitate a potent inhibition of target proteases. SPINT2 regulates cell proliferation, migration and invasion via a reduction in HGFA, leading to apoptosis and necrosis of uterine leiomyosarcoma cells.

参考文献:

1. Li J, et al. (2023). Exp Ther Med. Oct 9;26(6):546. 
2. Straus, M.R., et al. (2020). Virology. Apr;543:43-53. 
3. Heinz-Erian P, et al. (2009). Am J Hum Genet. 84(2):188-196.
4. Pereira, M.S., et al. (2016). J Histochem Cytochem. Jan;64(1):32-41.