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Recombinant Human Neuroserpin protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2819

Print datasheet

Synonyms

Serpin I1, Neuroserpin, Peptidase inhibitor 12, PI 12, PI12

验证数据展示

  • Purity of Recombinant Human Neuroserpin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Neuroserpin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Neuroserpin protein Thr17-Leu410 (Accession# Q99574) with a rabbit IgG Fc tag at the C-terminus.
基因ID 5274
蛋白编号 Q99574
预测分子量 70.7 kDa
SDS-PAGE 75-90 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.

参考文献:

1. Yang X, Fang Z, et al. (2022) Seizure. 103:137-147. 
2. Matsuda Y, Miura K, et al. (2016) Cancer Sci. 107(5):619-28. 
3. Mirshahvaladi S, Chitranshi N, et al. (2024) Proteomes. 12(1):7. 
4. Ranza E, Garcia-Tarodo S, et al. (2017) Am J Med Genet A. 173(9):2456-2460.