Recombinant Human Neuroserpin protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human Neuroserpin protein Thr17-Leu410 (Accession# Q99574) with a rabbit IgG Fc tag at the C-terminus. |
基因ID | 5274 |
蛋白编号 | Q99574 |
预测分子量 | 70.7 kDa |
SDS-PAGE | 75-90 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.
参考文献:
1. Yang X, Fang Z, et al. (2022) Seizure. 103:137-147. 2. Matsuda Y, Miura K, et al. (2016) Cancer Sci. 107(5):619-28. 3. Mirshahvaladi S, Chitranshi N, et al. (2024) Proteomes. 12(1):7. 4. Ranza E, Garcia-Tarodo S, et al. (2017) Am J Med Genet A. 173(9):2456-2460.