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Recombinant Human REG3A protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2893

Print datasheet

Synonyms

Hepatointestinal pancreatic protein, HIP, HIP/PAP, Pancreatitis-associated protein 1, Reg III-alpha

验证数据展示

  • Purity of Recombinant Human REG3A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human REG3A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human REG3A was greater than 90% as determined by SEC-HPLC.

    The purity of Human REG3A was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human REG3A protein Glu27-Asp175 (Accession# Q06141) with a rabbit IgG Fc tag at the C-terminus.
基因ID 5068
蛋白编号 Q06141
预测分子量 45.8 kDa
SDS-PAGE 40-47 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Regenerating islet-derived protein 3-alpha (REG3A), also known as hepatocarcinoma-intestine pancreas/pancreatic associated protein or HIP/PAP, is a secreted 16 kDa carbohydrate-binding protein that functions as an AMP against Gram-positive bacteria. REG3A is reported to be associated with diseases in a variety of organs and tissues such as pancreas, gastrointestinal tract, liver, heart, and skin. REG3A expression is highly upregulated in inflamed pancreas and gastrointestinal tract. The main biological functions of REG3A are related to cell proliferation, regeneration, resistance to cell death, and tissue repair after inflammatory injury.

参考文献:

1.Guo J. et al. (2021) Mol Cells. 44(9):647-657.
2.Wang L. et al. (2021) Bioengineered. 12(1):7644-7655.
3.Gonzalez P. et al. (2023) Commun Biol. 6(1):269.
4.Yu L. et al. (2023) Biomed Pharmacother. 169:115922.
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