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Recombinant Human Nectin 3 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2657

Print datasheet

Synonyms

Nectin-3, PVRL3, CD113, nectin 3, Nectin cell adhesion molecule 3

验证数据展示

  • Purity of Recombinant Human Nectin 3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Nectin 3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Nectin 3 protein Gly58-Asp400 (Accession# Q9NQS3-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 25945
蛋白编号 Q9NQS3-1
预测分子量 63.7 kDa
SDS-PAGE 70-100 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

PVRL3, also known as CD113 or Nectin3, belonging to the immunoglobulin-like cellular adhesion molecule family, plays a critical role in Ca2+-independent cellular adhesion and is involved in the regulation of the immune system through its interaction with the TIGIT receptor on T cells and Natural Killer (NK) cells. PVRL3 can influence tumor growth and metastasis by modulation of intercellular connections and cell signaling. In particular, in different cancer types (ovarian carcinoma, nasopharyngeal carcinoma, prostate carcinoma, and lung adenocarcinoma). Additionally, evidence suggests that PVRL3 may play a role in the tumor microenvironment, influencing the local immune response and interaction with stromal cells.

参考文献:

1. Gian Marco Leone. et al. (2024). Cells. 13(15):1299.
2. Yoshimasa Maniwa. et al. (2012). Thorac Cancer. 3(2):175-181.
3. Yin Zhao. et al. (2020). Cancer Commun (Lond). 40(12):721-737.
4. Anastasia V Suhovskih. et al. (2017). Cell Adh Migr. 11(1):39-53.
5. Baokang Wu. et al. (2021). J Exp Clin Cancer Res. 40(1):267.