Recombinant Human SELPLG/CD162 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human SELPLG protein Gln42-Cys320 (Accession# Q14242-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 6404 |
| 蛋白编号 | Q14242-1 |
| 预测分子量 | 55.1 kDa |
| SDS-PAGE | 80-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
SELPLG (selectin P ligand), also known as CD162 or PSGL-1, is a type I transmembrane mucin-like glycoprotein. It is an adhesion molecule expressed on the surface of neutrophils, monocytes, and most lymphocytes as a homodimer of approximately 230-250 kDa (PMID: 7545173; 1378449; 9353350). SELPLG plays a critical role in the early stages of inflammation due to its ability to bind E-selectin (CD62E), L-selectin (CD62L), and P-selectin (CD62P) (PMID: 35597982).
参考文献:
1. Vachino G. et al. (1995). J Biol Chem. 270(37):21966-21974. 2. Moore KL. et al. (1992). J Cell Biol. 118(2):445-456. 3. Borges E. et al. (1997). J Biol Chem. 272(45):28786-28792. 4. Burnie J. et al. (2022). Retrovirology. 19(1):9.
