Recombinant Human TrkB protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TrkB protein Cys32-His430 (Accession# Q16620-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 4915 |
| 蛋白编号 | Q16620-1 |
| 预测分子量 | 70.2 kDa |
| SDS-PAGE | 77-110 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Tropomyosin-related kinase B (TrkB) is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. It is a high-affinity neurotrophin receptor that is crucial in regulating neuronal survival, differentiation, and synaptic plasticity. TrkB is primarily localized to the cell membrane, where it functions as a receptor for neurotrophins. It is known to exist as pre-formed dimers on the cell surface, with the potential to switch between active and inactive conformations. Abnormal activation of TrkB, caused by overexpression or gene fusions, has been implicated in the initiation and progression of various types of neurogenic tumors.
参考文献:
1.Kot EF. et al. (2024). Nat Commun. 15(1):9316. 2.Li Y. et al. (2023). J Pathol Clin Res. 9(2):89-99. 3.Klein R. et al. (1991). Cell. 66(2):395-403. 4.Ohira K. et al. (2009). Curr Neuropharmacol. 7(4):276-285.
