Recombinant Human MUC1/CA15-3 protein (hFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
hFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human MUC1 protein Ser24-Ser380 (Accession# P15941-1) with a human IgG1 Fc tag at the C-terminus. |
| 基因ID | 4582 |
| 蛋白编号 | P15941-1 |
| 预测分子量 | 61.2 kDa |
| SDS-PAGE | 70-80 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
MUC1, also known as CA15-3, is a type I transmembrane glycoprotein expressed by various epithelial cells of the female reproductive tract, lung, breast, kidney, stomach, and pancreas. MUC1 is transcribed as a large precursor gene product, and upon translation, is cleaved in the endoplasmic reticulum, yielding two subunits: the large extracellular N-terminal subunit (MUC1-N, about 120-200 kDa) and the small cytoplasmic C-terminal subunit (MUC1-C, about 23-30 kDa). Among the known mucins, MUC1 is best studied and plays crucial roles in regulating many cellular properties, including cell proliferation, apoptosis, adhesion, and invasion. MUC1 is overexpressed in a wide range of human epithelial malignancies.
参考文献:
1. S J Gendler, et al. (1995) Annu Rev Physiol. 57:607-34. 2. Pankaj K Singh, et al. (2006) Trends Cell Biol. 16(9):467-76. 3. Ming-Kwang Shyu, et al. (2008) Biol Reprod. 79(2):233-9. 4. Sritama Nath, et al. (2014) Trends Mol Med. 20(6):332-42. 5. Guang Wu, et al. (2018) Theranostics. 8(1):78-91.
