Recombinant Human MIF protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human MIF protein Pro2-Ala115 (Accession# P14174) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 4282 |
| 蛋白编号 | P14174 |
| 预测分子量 | 38.6 kDa |
| SDS-PAGE | 40-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in 20 mM PB, 150 mM NaCl, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Macrophage migration inhibitory factor (MIF) is a homo-trimeric protein that acts as a pleiotropic pro-inflammatory cytokine. It contributes to the pathogenesis of many autoimmune diseases through its upstream immunoregulatory function and its polymorphic genetic locus. It is involved in multiple functions including leukocyte recruitment, inflammation, immune responses, cell proliferation, tumourigenesis and glucocorticoid (GC) counterregulation.
参考文献:
1.Lue H. et al. (2002) Microbes Infect. 4(4):449-60. 2.Martin J. et al. (2009) FASEB J. 23(3):720-30. 3.Bucala, R. (1996) FASEB J. 10(14):1607-13. 4.Gore Y. et al. (2008) J Biol Chem. 283(5):2784-92.
