Recombinant Human Meprin beta Subunit/MEP1B protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Meprin beta Subunit protein Thr23-Thr652 (Accession# Q16820) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 4225 |
| 蛋白编号 | Q16820 |
| 预测分子量 | 97.5 kDa |
| SDS-PAGE | 92-130 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Meprin A subunit beta (MEP1B) is a part of the 'astacin family' and 'metzincin superfamily' of metalloendopeptidases. It is a highly glycosylated, disulfide-linked oligomeric protease composed of one or two evolutionarily related subunits, α and β. MEP1B is implicated in the processing of inflammatory mediators, including cytokines and chemokines, which provides a link to its involvement in inflammatory disorders. It also has been associated with several diseases, particularly those involving barrier breakdown such as Alzheimer's disease, kidney disruption, and inflammatory bowel disease.
参考文献:
1.Herzog C. et al. (2019) Cytokine. 114:18-25. 2.Jiang W. et al. (2000) Gene. 248(1-2):77-87. 3.Gindorf M. et al. (2021) J Cereb Blood Flow Metab. 41(1):31-44.
