Recombinant Human LILRA2 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human LILRA2 protein Gly24-Asn449 (Accession# Q8N149-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 11027 |
| 蛋白编号 | Q8N149-1 |
| 预测分子量 | 73.2 kDa |
| SDS-PAGE | 80-110 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
LILRA2, also known as CD85H and ILT1, is a member of the subfamily A class of LIR receptors (LILRAs). LILRA2 is an activating receptor highly expressed in inflammatory tissues, and is involved in granulocyte and macrophage activation. Cross-linking of LILRA2 on the surface of leukocytes recruits protein tyrosine kinase signaling molecules that lead to cellular activation. It can inhibit dendritic cell differentiation and antigen presentation and suppresses innate immune responses. It plays a role in the innate immune responses against microbial infection and modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes.
参考文献:
1. Mamegano K, et al. (2008). Genes Immun. 9(3):214-223. 2. Nakajima H, et al. (1999). J Immunol. 162(1):5-8. 3. Lu HK, et al. (2012). PLoS One.7(8).
