Recombinant Human NKG2C/CD159c protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human NKG2C protein Ile94-Leu231 (Accession# P26717) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3822 |
| 蛋白编号 | P26717 |
| 预测分子量 | 41.8 kDa |
| SDS-PAGE | 45-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
NKG2C, also known as KLRC2 and CD159c, is an activating receptor of natural killer (NK) cells and plays a significant role in immune surveillance and host resistance against viruses and tumors (PMID: 36899273). It is an immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PMID: 30134159; 37264229; 9754572).
参考文献:
1. Siemaszko J. et al. (2023). Arch Immunol Ther Exp (Warsz). 71(1):9. 2. Rölle A. et al. (2018). Cell Rep. 24(8):1967-1976.e4. 3. Lin Z. et al. (2023). Nat Immunol. 24(7):1087-1097. 4. Llano M. et al. (1998). Eur J Immunol. 28(9):2854-2863.
