Recombinant Human KIR3DL1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human KIR3DL1 protein His22-His340 (Accession# Q8N6C9) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3811 |
| 蛋白编号 | Q8N6C9 |
| 预测分子量 | 61.5 kDa |
| SDS-PAGE | 70-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR3DL1 is a receptor on natural killer (NK) cells for HLA Bw4 allele. It inhibits the activity of NK cells thus preventing cell lysis. KIR3DL1 and KIR3DS1 are highly homologous.
参考文献:
1. O'Connor GM, et al. (2013). Crit Rev Immunol. 33(3):203-18. 2, Martin A M, et al. (2000). Immunogenetics, 51(4-5), 268–280. 3. Díaz-Peña R., et al. (2010). Arthritis Rheum. Apr;62(4):1000-6.
