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Recombinant Human JAM2 protein (mFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

mFc Tag

生物活性

未测试

Cat no : Eg4040

Print datasheet

Synonyms

C21orf43, CD322, JAM-2, JAMB, JAM-B

验证数据展示

  • Purity of Recombinant Human JAM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human JAM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human JAM2 was greater than 90% as determined by SEC-HPLC.

    The purity of Human JAM2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human JAM2 protein Phe29-Asn236 (Accession# P57087-1) with a mouse IgG Fc tag at the C-terminus.
基因ID 58494
蛋白编号 P57087-1
预测分子量 49.9 kDa
SDS-PAGE 52-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Junctional adhesion molecules (JAMs) are integral membrane proteins belonging to the immunoglobulin (Ig) superfamily. JAMs are expressed by leukocytes, platelets, endothelial, and epithelial cells and localized at the tight junction of polarized cells and on the cell surface of leukocytes. JAM-2, also known as VE-JAM or JAM-B, is specifically expressed in lymphatic endothelial cells and endothelial venules. JAM2 regulates cell-cell adhesion and signaling by interacting with other tight junction proteins such as PAR-3 and ZO-1.

参考文献:

1. Ebnet K, et al. (2004). J Cell Sci.1;117(Pt 1):19-29. 
2. Garrido-Urbani S, et al. (2014). Cell Tissue Res. 355(3):701-15.
3. Aurrand-Lions M, et al. (2001). Blood.15;98(13):3699-707.
4. Ebnet K, et al. (2003). J Cell Sci. 1;116(Pt 19):3879-91.
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