Recombinant Human JAM2 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human JAM2 protein Phe29-Asn236 (Accession# P57087-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 58494 |
| 蛋白编号 | P57087-1 |
| 预测分子量 | 48.8 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Junctional adhesion molecules (JAMs) are integral membrane proteins belonging to the immunoglobulin (Ig) superfamily. JAMs are expressed by leukocytes, platelets, endothelial, and epithelial cells and localized at the tight junction of polarized cells and on the cell surface of leukocytes. JAM-2, also known as VE-JAM or JAM-B, is specifically expressed in lymphatic endothelial cells and endothelial venules. JAM2 regulates cell-cell adhesion and signaling by interacting with other tight junction proteins such as PAR-3 and ZO-1.
参考文献:
1.Ebnet, Klaus et al. Journal of cell science vol. 117,Pt 1 (2004): 19-29. 2.Garrido-Urbani, S et al. Cell and tissue research vol. 355,3 (2014): 701-15. 3.Aurrand-Lions, M et al. Blood vol. 98,13 (2001): 3699-707. 4.Ebnet, Klaus et al. Journal of cell science vol. 116,Pt 19 (2003): 3879-91.