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Recombinant Human IFNA1 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1177

Print datasheet

Synonyms

IFNA13, IFN alpha 1/13, IFNA1, Interferon alpha 1/13

验证数据展示

  • Purity of Recombinant Human IFNA1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IFNA1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human IFNA1 protein Cys24-Glu189 (Accession# P01562) with a His tag at the C-terminus.
基因ID 3447/3439
蛋白编号 P01562
预测分子量 20.2 kDa
SDS-PAGE 16-18 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

IFNA1 is a member of the Type I IFN (1) family best known for their antiviral activity. It is a key cytokine regulating the activity of B cells, T-helper cells (Th cells), cDCs and natural killer cells (NK cells). Interferon-alpha induces B cell maturation into plasma cells and immunoglobulin production. Interferon-alpha plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Interferon-alpha was the first cytokine to show clinical benefit in the treatment of certain types of cancer, including melanoma, chronic myelogenous leukemia, and renal cancer.

参考文献:

1. Lande R. et al. (2010). Ann N Y Acad Sci. 1183: 89-103.
2. Poeck H. et al. (2004). Blood. 103: 3058-64.
3. Lindau D. et al. (2013). Ann Rheum Dis. Sep 7
4. Belardelli F. et al. (2002). Cytokine Growth Factor Rev. 13: 119-34.
5. Brassard DL. et al. (2002). J Leukoc Biol. 71: 565-81.