Recombinant Human IL-21R protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IL-21R protein Cys20-Pro236 (Accession# Q9HBE5) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 50615 |
| 蛋白编号 | Q9HBE5 |
| 预测分子量 | 51.3 kDa |
| SDS-PAGE | 60-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL21R, a receptor for interleukin-21, belongs to the type I cytokine receptor family. IL21R has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3.
参考文献:
1. Hecker A. et al. (2009). Immunobiology. 214(1):41-9. 2. Wang T. et al. (2015). Arterioscler Thromb Vasc Biol. 35(5):1218-25. 3. Yang DJ. et al. (2016). Zhongguo Dang Dai Er Ke Za Zhi. 18(5):466-71.
