Recombinant Human ICAM-3/CD50 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ICAM-3 protein Gln30-His485 (Accession# P32942) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3385 |
| 蛋白编号 | P32942 |
| 预测分子量 | 75.7 kDa |
| SDS-PAGE | 90-130 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ICAM3, also known as CD50 or CDW50, is a protein-coding gene in humans. It encodes a member of the intercellular adhesion molecule (ICAM) family, which are type I transmembrane glycoproteins containing immunoglobulin-like C2-type domains. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. ICAM3 is expressed with biased expression in bone marrow, spleen, and 12 other tissues. It is found in epithelium, endothelium, leukocytes, fibroblasts, erythrocytes, platelets, and neurons.
参考文献:
1. Fawcett J. et al. (1992). Nature. 360(6403):481-484. 2. Kristóf E. et al. (2013). Apoptosis. 18(10):1235-1251. 3. Shen W. et al. (2018). Cancer Lett. 422:29-43.
