Recombinant Human Hemopexin/HPX protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Hemopexin protein Thr24-His462 (Accession# P02790) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3263 |
| 蛋白编号 | P02790 |
| 预测分子量 | 75.3 kDa |
| SDS-PAGE | 90-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Hemopexin (HPX) is a liver-synthesized plasma glycoprotein consisting of a single 60 kDa peptide chain. HPX has a high-affinity heme-binding capacity, and its main physiological functions are to bind and transport toxic free heme, prevent heme-induced oxidative stress and loss of heme-bound iron, and to counteract heme toxicity caused by severe acute or chronic hemolysis. HPX is mainly expressed in the liver, central and peripheral nervous system, and has been closely associated with the pathology of many diseases, including acute or chronic hemolytic diseases, liver diseases, infectious diseases, etc. It is considered as a biomarker for assessing heme load in many hemolytic pathologies.
参考文献:
1. Ashouri R, et al. (2021). Int J Mol Sci. 22(12):6408. 2. Li Y, et al. (2023). Front Immunol. 14:1274333. 3. Bogdanov P, et al. (2023). Diabetes. 72(12):1841-1852. 4. HvidbergV, et al. (2005). Blood. 106(7): 2572-2579.
