Recombinant Human CD89 protein (rFc Tag) (HPLC verified)
种属
Human
纯度
>90 %, SDS-PAGE
>90 %, SEC-HPLC
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90 %, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD89 protein Gln22-Asn227 (Accession# P24071-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 2204 |
| 蛋白编号 | P24071-1 |
| 预测分子量 | 49.8 kDa |
| SDS-PAGE | 55-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes macrophages, and platelets. CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89. CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies.
参考文献:
1. Cambier A, et al. (2022). Kidney Int. Feb;101(2):274-287. 2. de Tymowski C, et al. (2019). Cell Rep. Apr 16;;27(3):762-775.e5. 3. Lua WH, et al. (2017). Cell Cycle. Mar 4;16(5):457-467. 4. van Delft MAM, et al. (2023). Front Immunol. Apr 4;14:1118539.
