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Recombinant Human EPHA3 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2951

Print datasheet

Synonyms

EC:2.7.10.1, EK4, EPH like kinase 4, EPH receptor A3, EPH-like kinase 4

验证数据展示

  • Purity of Recombinant Human EPHA3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human EPHA3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human EPHA3 was greater than 90% as determined by SEC-HPLC.

    The purity of Human EPHA3 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human EPHA3 protein Glu21-Gln541 (Accession# P29320-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 2042
蛋白编号 P29320-1
预测分子量 84.9 kDa
SDS-PAGE 85-110 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Ephrin type-A receptor 3 (EPHA3) is a member of the EPH receptor family of tyrosine kinases. These receptors play a crucial role in developmental processes, particularly in the nervous system, and are involved in cell adhesion, migration, and signaling. EPHA3 binds promiscuously membrane-bound ephrin family ligands on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It has been correlated with various human malignancies, including hematologic disorders, gastric cancer, glioblastoma multiforme, colorectal cancer, etc.

参考文献:

1.Lawrenson ID. et al. (2002). J Cell Sci. 115(Pt 5):1059-1072.
2.London M. et al. (2020). Mol Biol Rep. 47(7):5523-5533.
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