Recombinant Human Ephrin B3 protein (rFc Tag) (HPLC verified)
种属
Human
纯度
>90 %, SDS-PAGE
>90 %, SEC-HPLC
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90 %, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Ephrin B3 protein Leu28-Pro226 (Accession# Q15768) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1949 |
| 蛋白编号 | Q15768 |
| 预测分子量 | 48.0 kDa |
| SDS-PAGE | 50-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
EFNB3, or ephrin B3, is a member of the ephrin gene family, which encodes a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors. EFNB3 is highly expressed in the brain and interacts with GRIP1 and GRIP2, which are key molecules in EFNB reverse signalingEFNB3 is highly expressed in the brain and interacts with GRIP1 and GRIP2, which are key molecules in EFNB reverse signaling. EFNB3 has also been implicated in blood pressure control and vascular smooth muscle cell (VSMC) contractility. Studies have shown that EFNB3 deletion can lead to increased blood pressure in a sex-dependent manner, with vascular smooth muscle being the target tissue mediating this effect (PMID: 26851246).
参考文献:
1. Wang Y. et al. (2016). Am J Physiol Heart Circ Physiol. 310(7):H861-72.

