Recombinant Human EDA protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human EDA protein Glu63-Ser391 (Accession# Q92838-1) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 1896 |
| 蛋白编号 | Q92838-1 |
| 预测分子量 | 62.0 kDa |
| SDS-PAGE | 35-40 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
EDA (ectodysplasin A), which belongs to the tumor necrosis factor (TNF) family, causes cell death, proliferation, or differentiation. EDA primarily regulates the induction, morphogenesis, and/or maintenance of structures of cutaneous origin (e.g., teeth, hair, sweat glands, and several other glands). Mutations in the gene responsible for EDA signaling result in hypohidrotic ectodermal dysplasia (HED), an A congenital genetic disorder accompanied by malformations of the skin attachments. Recent studies have shown that EDA and its receptors regulate cancer cell proliferation, apoptosis, differentiation, and migration, which may regulate tumorigenesis and cancer progression. The EDA pathway has also been shown to be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and type II diabetes by regulating glucose and lipid metabolism. (PMID: 36012178)
参考文献:
1. Yang R,et al. Int J Mol Sci. 2022;23(16):8911. 2. Ou S, et al. Int J Mol Sci. 2022;23(24):15700. 3. Deng X,et al. J Diabetes Res. 2023;2023:5087761.
