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Recombinant Human CRTAM/CD355 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1541

Print datasheet

Synonyms

CRTAM, CD355, Class-I MHC-restricted T-cell-associated molecule, Cytotoxic and regulatory T-cell molecule

验证数据展示

  • Purity of Recombinant Human CRTAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CRTAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CRTAM protein Ser18-Ser286 (Accession# O95727-1) with a His tag at the C-terminus.
基因ID 56253
蛋白编号 O95727-1
预测分子量 31.0 kDa
SDS-PAGE 40-68 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Cytotoxic and regulatory T cell molecule (CRTAM, also known as CD355) is an immunoglobulin-superfamily transmembrane protein with V and C1-like Ig domains, which is involved in epithelial cell adhesion. CRTAM is critical to instruct the differentiation of CD4+ cytotoxic T cells (CTL) through the induction of eomesodermin and CTL-related genes. It also regulates CD8+ T cell retention within the lymph node and eventually effector function. The predicted molecular weight of CRTAM is 43 kDa. Due to glycosylation, the observed molecular weight of CRTAM can be apparent at ~80 kDa.

参考文献:

1.Yeh JH, et al. (2008). Cell. 132(5):846-59.
2.Garay E, et al. (2010). J Cell Biochem. 111(1):111-22.
3.Takeuchi A, et al. (2016). J Exp Med. 213(1):123-38.
4.Takeuchi A, et al. (2009). J Immunol. 183(7):4220-8.
5.Patiño-Lopez G, et al. (2006). J Neuroimmunol. 171(1-2):145-55.