Recombinant Human CORT protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CORT protein Gln77-Lys105 (Accession# O00230) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1325 |
| 蛋白编号 | O00230 |
| 预测分子量 | 29.7 kDa |
| SDS-PAGE | 32-38 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cortistatin (CORT) is a multifunctional neuropeptide that inhibits tumor development in a variety of malignant tumors. CORT is widely expressed in the nervous, endocrine, and immune systems, with the best expression in inhibitory neurons in the cerebral cortex. CORT plays a critical role in a variety of physiological and disease processes, including immune responses, heart disease and neurological degeneration. Its overexpression significantly reduces the ability of glioma cells to proliferate and migrate in vitro and to form tumors in vivo. (PMID: 38292193)
参考文献:
1, He Z, et al. Genes Dis. 2023;11(3):100977. 2. Zhao Y, et al. Theranostics. 2020;10(15):7015-7033. 3. Liang J,et al. Cardiovasc Diagn Ther. 2019;9(4):394-399. 4. Gao Y, et al. Commun Biol. 2024;7(1):132.
