Recombinant Human CD93 protein (mFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD93 protein Ala24-Lys580 (Accession# Q9NPY3) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 22918 |
| 蛋白编号 | Q9NPY3 |
| 预测分子量 | 84.7 kDa |
| SDS-PAGE | 100-130 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is a transmembrane glycoprotein, that belongs to the C-type lectin domain (CTLD) group 14 family of transmembrane glycoproteins together with thrombomodulin, CLEC14A, and CD248. This protein family has a similar ectodomain architecture and is involved in several cell processes including angiogenesis, inflammation, and cell adhesion. CD93 is predominantly co-expressed on tumor and stromal cells, such as endothelial cells, cancer-associated fibroblasts(CAFs), neutrophils, T cells, macrophages, M1 and M2 macrophages. Several immune-related signaling pathways were enriched based on CD93 expression, including immune cell activation and migration, focal adhesion, leukocyte transendothelial migration, oxidative phosphorylation, and complement.
参考文献:
1. Giovanni Tossetta. et al. (2023). Cells. 12(13):1778. 2. Kabir A Khan. et al. (2019). FEBS J. 286(17):3299-3332. 3. Aiyuan Guo. et al. (2022). Front Immunol. 13:907182.
