Recombinant Human CD59 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD59 protein Leu26-Asn102 (Accession# P13987-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 966 |
| 蛋白编号 | P13987-1 |
| 预测分子量 | 35.2 kDa |
| SDS-PAGE | 38-48 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD59, also named as MIC11, MIN1, MIN2, MIN3, MSK21, MIRL, MACIF, HRF20 and 1F5 antigen, is a cell surface molecule glycoprotein with MW 18-25 kDa. It acts as a determinant of proximal-distal cell identity. CD59 acts by binding to the C8 and/or C9 complements of the assembling membrane attack complex (MAC), thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. It is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
参考文献:
1. Imre Farkas, et al. (2002) J Physiol. 539(Pt 2):537-45. 2. S A Rollins, et al. (1990) J Immunol. 144(9):3478-83. 3. Emanuela Marcenaro, et al. (2003) Eur J Immunol. 33(12):3367-76. 4. Xi-He Xie, et al. (2012) Cell Immunol. 274(1-2):1-11.
