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Recombinant Human CCL16 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3134

Print datasheet

Synonyms

CCL16/LEC, C C motif chemokine 16, CCL 16, CCL-16

验证数据展示

  • Purity of Recombinant Human CCL16 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CCL16 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human MerTK was greater than 90% as determined by SEC-HPLC.

    The purity of Human MerTK was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CCL16 protein Gln24-Gln120 (Accession# O15467) with a rabbit IgG Fc tag at the C-terminus.
基因ID 6360
蛋白编号 O15467
预测分子量 37.2 kDa
SDS-PAGE 38-48 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Chemokine (C-C motif) ligand 16 (CCL16), also known as LEC (Liver-expressed chemokine), Monotactin-1 (MTN-1), IL-10-inducible chemokine, etc., is a small-molecule cytokine that belongs to CC chemokine family. CCL16 is expressed predominantly in the liver, thymus and spleen and has chemotactic activity towards lymphocytes and monocytes, playing a role in immunity and inflammation. (PMID: 33500726) CCL16 affects cells by binding to cell surface chemokine receptors (i.e., CCR1, CCR2, CCR5, and CCR8), and is also of interest in the tumor microenvironment, where it may influence tumor progression by modulating the tumor immune microenvironment. Studies have shown that CCL16 is a prognostic biomarker for triple-negative breast and lung cancer metastases.

参考文献:

1. Shen W, et al. Theranostics. 2021;11(5):2297-2317.                                                
2. Weiergräber OH, et al. Biomolecules. 2022;12(11):1588.                                        
3. Chi HC, et al. Am J Cancer Res. 2024;14(7):3600-3613.                                           
4. Dai Z, et al. Front Immunol. 2024;14:1299953.
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