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Recombinant Human Carbonic Anhydrase 6/CA6 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2963

Print datasheet

Synonyms

CA6, CA VI, Carbonate dehydratase VI, Carbonic anhydrase 6, CA-VI

验证数据展示

  • Purity of Recombinant Human Carbonic Anhydrase 6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Carbonic Anhydrase 6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human Carbonic Anhydrase 6 was greater than 90% as determined by SEC-HPLC.

    The purity of Human Carbonic Anhydrase 6 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Carbonic Anhydrase 6 protein Gln18-Asn308 (Accession# P23280-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 765
蛋白编号 P23280-1
预测分子量 59.6 kDa
SDS-PAGE 58-68 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CA6 (Carbonic anhydrase VI ) is a member of CA family proteins that play a central role in pH regulation and electrolyte balance. CA6 is also known as gustin, is a zinc-containing secreted protein which catalyzes the hydration of carbon hydroxide in saliva. CA6 is specifically expressed in the salivary gland of a number of mammalian species. The amino acid sequences are highly conserved across the species. And it was reported that decreasing of CA6 protein was associated with loss of taste and pathological morphology of taste buds.

参考文献:

1.	Choi JH, Lee J, etal. (2017)  Oncotarget. 28;8(13):21253-21265. 
2.	Thatcher BJ, Doherty AE, etal. (1998) Biochem Biophys Res Commun. 29;250(3):635-41. 
3.	Li Y, Pan J. (2024) Clin Oral Investig. 30;28(9):508. 
4.	Nicolazzi C. (2020) Mol Cancer Ther. 19(8):1660-1669.